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Sandy Cohen, photo courtesy of Miller Mobley for TIME

In this series of stunning photos, Time Magazine features the many women who elected prophylactic double mastectomy long before the news of Angelina’s BRCA1 mutation and surgery broke in Spring 2013.

Penn Medicine’s Basser Research Center for BRCA works closely with many of the women featured, including Sandy Cohen, Karen Kramer, Lisa Schlager, and Diane Rose of Facing Our Risk of Cancer Empowered (FORCE) and Dr. Elizabeth Chabner Thompson of Best Friends for Life (BFFL Co).

See the photos and read the stories here.

The Basser Research Center for BRCA is dedicated to delivering cutting edge research in the basic and clinical sciences to advanced the care of individuals who carry BRCA mutations.