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The Hospitals of the University of Pennsylvania-Penn Presbyterian (HUP/PPMC) are ranked among the top hospitals in the United States by U.S. News & World Report. The publication's prestigious annual ranking of hospitals placed HUP/PPMC #7 in its "Honor Roll" recognition for excellence in multiple specialties.

The Hospitals of the University of Pennsylvania-Penn Presbyterian are also ranked #1 in the region, while Pennsylvania Hospital (PAH) is ranked #6 in the region and Chester County Hospital is ranked #17 in the region.